Ancestry inference using reference labeled clusters of haplotypes

Ancestry inference using reference labeled clusters of haplotypes

Abstract Background We present ARCHes, a fast and accurate haplotype-based approach for inferring an individual’s ancestry composition. Our approach works by modeling haplotype diversity from a large, admixed cohort of hundreds of thousands, then annotating those models with population information f...

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Bibliographic Details
Main Authors: Yong Wang, Shiya Song, Joshua G. Schraiber, Alisa Sedghifar, Jake K. Byrnes, David A. Turissini, Eurie L. Hong, Catherine A. Ball, Keith Noto
Format: Article
Language:English
Published: BMC 2021-09-01
Series:BMC Bioinformatics
Subjects:
ARCHes
Ancestry inference
Haplotype modeling
Local ancestry
HMM
RFMix
Online Access:https://doi.org/10.1186/s12859-021-04350-x

Internet

https://doi.org/10.1186/s12859-021-04350-x

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