The insulin receptor cellular IRES confers resistance to eIF4A inhibition
Under conditions of stress, such as limited growth factor signaling, translation is inhibited by the action of 4E-BP and PDCD4. These proteins, through inhibition of eIF4E and eIF4A, respectively, impair cap-dependent translation. Under stress conditions FOXO transcription factors activate 4E-BP exp...
Main Authors: | , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
eLife Sciences Publications Ltd
2013-07-01
|
Series: | eLife |
Subjects: | |
Online Access: | https://elifesciences.org/articles/00542 |