APP, PSEN1, and PSEN2 Variants in Alzheimer’s Disease: Systematic Re-evaluation According to ACMG Guidelines

APP, PSEN1, and PSEN2 Variants in Alzheimer’s Disease: Systematic Re-evaluation According to ACMG Guidelines

The strategies of classifying APP, PSEN1, and PSEN2 variants varied substantially in the previous studies. We aimed to re-evaluate these variants systematically according to the American college of medical genetics and genomics and the association for molecular pathology (ACMG-AMP) guidelines. In ou...

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Bibliographic Details
Main Authors: Xuewen Xiao, Hui Liu, Xixi Liu, Weiwei Zhang, Sizhe Zhang, Bin Jiao
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-06-01
Series:Frontiers in Aging Neuroscience
Subjects:
Alzheimer’s disease
ACMG-AMP guidelines
APP
PSEN1
PSEN2
re-evaluation
Online Access:https://www.frontiersin.org/articles/10.3389/fnagi.2021.695808/full

Internet

https://www.frontiersin.org/articles/10.3389/fnagi.2021.695808/full

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