Tetrandrine sensitizes nasopharyngeal carcinoma cells to irradiation by inducing autophagy and inhibiting MEK/ERK pathway

Tetrandrine sensitizes nasopharyngeal carcinoma cells to irradiation by inducing autophagy and inhibiting MEK/ERK pathway

Abstract Radioresistance was the main reason for local recurrence and metastasis of nasopharyngeal carcinoma. Tetrandrine is reported as an antitumor drug via inducing cell cycle arrest and apoptosis. In this study, the radiosensitization effects of maximum noncytotoxic doses of tetrandrine in nasop...

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Bibliographic Details
Main Authors: Jun Wang, Zhouzhou Yao, Xiaoping Lai, Hongwei Bao, Yue Li, Shuaixiang Li, Lihong Chang, Gehua Zhang
Format: Article
Language:English
Published: Wiley 2020-10-01
Series:Cancer Medicine
Subjects:
autophagy
MEK/ERK pathway
nasopharyngeal carcinoma
radiosensitization
tetrandrine
Online Access:https://doi.org/10.1002/cam4.3356

Internet

https://doi.org/10.1002/cam4.3356

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