CXCR4 knockdown prevents inflammatory cytokine expression in macrophages by suppressing activation of MAPK and NF-κB signaling pathways

CXCR4 knockdown prevents inflammatory cytokine expression in macrophages by suppressing activation of MAPK and NF-κB signaling pathways

Abstract Background Recent evidence has shown that C-X-C chemokine receptor type 4 (CXCR4) plays a crucial role in acute lung injury (ALI). Macrophages are key factors in the pathogenesis of ALI. The aim of this study was to investigate the role of CXCR4 in macrophages after lipopolysaccharide (LPS)...

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Bibliographic Details
Main Authors: Xue Tian, Guogang Xie, Hui Xiao, Fengming Ding, Wuping Bao, Min Zhang
Format: Article
Language:English
Published: BMC 2019-07-01
Series:Cell & Bioscience
Subjects:
CXCR4
IL-6
TNF-α
Macrophage
MAPK
NF-κB
Online Access:http://link.springer.com/article/10.1186/s13578-019-0315-x

Internet

http://link.springer.com/article/10.1186/s13578-019-0315-x

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