Mutant p53 Mediates Sensitivity to Cancer Treatment Agents in Oesophageal Adenocarcinoma Associated with MicroRNA and SLC7A11 Expression

Mutant p53 Mediates Sensitivity to Cancer Treatment Agents in Oesophageal Adenocarcinoma Associated with MicroRNA and SLC7A11 Expression

<i>TP53</i> gene mutations occur in 70% of oesophageal adenocarcinomas (OACs). Given the central role of p53 in controlling cellular response to therapy we investigated the role of mutant (mut-) p53 and SLC7A11 in a CRISPR-mediated JH-EsoAd1 <i>TP53</i> knockout model. Respon...

Full description

Bibliographic Details
Main Authors: Ann-Kathrin Eichelmann, George C. Mayne, Karen Chiam, Steven L. Due, Isabell Bastian, Frederike Butz, Tingting Wang, Pamela J. Sykes, Nicholas J. Clemons, David S. Liu, Michael Z. Michael, Christos S. Karapetis, Richard Hummel, David I. Watson, Damian J. Hussey
Format: Article
Language:English
Published: MDPI AG 2021-05-01
Series:International Journal of Molecular Sciences
Subjects:
radioresistance
chemoresistance
oestrogen receptor modulator
oesophageal cancer
miRNA
SLC7A11
Online Access:https://www.mdpi.com/1422-0067/22/11/5547

Internet

https://www.mdpi.com/1422-0067/22/11/5547

Similar Items