Effects of sorafenib on intra-tumoral interstitial fluid pressure and circulating biomarkers in patients with refractory sarcomas (NCI protocol 6948).

Effects of sorafenib on intra-tumoral interstitial fluid pressure and circulating biomarkers in patients with refractory sarcomas (NCI protocol 6948).

Sorafenib is a multi-targeted tyrosine kinase inhibitor with therapeutic efficacy in several malignancies. Sorafenib may exert its anti-neoplastic effect in part by altering vascular permeability and reducing intra-tumoral interstitial hypertension. As correlative science with a phase II study in pa...

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Bibliographic Details
Main Authors: Chandrajit P Raut, Yves Boucher, Dan G Duda, Jeffrey A Morgan, Richard Quek, Marek Ancukiewicz, Johanna Lahdenranta, J Paul Eder, George D Demetri, Rakesh K Jain
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3274514?pdf=render

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http://europepmc.org/articles/PMC3274514?pdf=render

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