Progression to AIDS in SIV-infected rhesus macaques is associated with distinct KIR and MHC class I polymorphisms and NK cell dysfunction

Progression to AIDS in SIV-infected rhesus macaques is associated with distinct KIR and MHC class I polymorphisms and NK cell dysfunction

Killer cell immunoglobulin-like receptors (KIR) regulate the activity of NK cells and have been shown to be associated with susceptibility to a number of human infectious diseases. Here, we analysed NK cell function and genetic associations in a cohort of 52 rhesus macaques experimentally infected w...

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Bibliographic Details
Main Authors: Christina eAlbrecht, Dörthe eMalzahn, Markus eBrameier, Meike eHermes, Aftab A Ansari, Lutz eWalter
Format: Article
Language:English
Published: Frontiers Media S.A. 2014-11-01
Series:Frontiers in Immunology
Subjects:
Epistasis
aids
Genetic polymorphism
Virus infection
killer cell immunoglobulin-like receptors
MHC class I ligands
Online Access:http://journal.frontiersin.org/Journal/10.3389/fimmu.2014.00600/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fimmu.2014.00600/full

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