Stability and nuclear localization of yeast telomerase depend on protein components of RNase P/MRP

Stability and nuclear localization of yeast telomerase depend on protein components of RNase P/MRP

Pop1 and 6 are subunits of RNase P and RNase MRP, which process ribosomal and tRNAs. The authors show that when Pop1 and 6 are impaired, the telomerase subunit Est1 binds telomerase RNA at normal levels, but the binding is unstable. As a result, nuclear import of the telomerase holoenzyme is inhibit...

Full description

Bibliographic Details
Main Authors: P. Daniela Garcia, Robert W. Leach, Gable M. Wadsworth, Krishna Choudhary, Hua Li, Sharon Aviran, Harold D. Kim, Virginia A. Zakian
Format: Article
Language:English
Published: Nature Publishing Group 2020-05-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-020-15875-9

Internet

https://doi.org/10.1038/s41467-020-15875-9

Similar Items