Hydrophilic Interaction Liquid Chromatography Coupled to Mass Spectrometry and Multivariate Analysis of the <i>De Novo</i> Pyrimidine Pathway Metabolites

In this study, we describe the optimization of a Hydrophilic Interaction Liquid Chromatography coupled to mass spectrometry (HILIC-MS) method for the evaluation of 14 metabolites related to the <i>de novo</i> synthesis of pyrimidines (<i>dn</i>SP) while using multivariate ana...

Full description

Bibliographic Details
Main Authors: Paula Galeano Garcia, Barbara H. Zimmermann, Chiara Carazzone
Format: Article
Language:English
Published: MDPI AG 2019-07-01
Series:Biomolecules
Subjects:
Online Access:https://www.mdpi.com/2218-273X/9/8/328