Clinical significance of programmed death 1 ligand-1 (CD274/PD-L1) and intra-tumoral CD8+ T-cell infiltration in stage II–III colorectal cancer

Clinical significance of programmed death 1 ligand-1 (CD274/PD-L1) and intra-tumoral CD8+ T-cell infiltration in stage II–III colorectal cancer

Abstract Programmed cell death-1 (PDCD1/PD-1) and its ligand programmed cell death 1 ligand 1 (CD274/PD-L1) have been reported to suppress anti-tumor T cell-mediated immune responses. However, the clinical significance of CD274 in colorectal cancer were still elusive. We aim to clarify the relations...

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Bibliographic Details
Main Authors: Chih-Yang Huang, Shu-Fen Chiang, Tao-Wei Ke, Tsung-Wei Chen, Ying-Shu You, William Tzu-Liang Chen, K. S. Clifford Chao
Format: Article
Language:English
Published: Nature Publishing Group 2018-10-01
Series:Scientific Reports
Subjects:
Tumor-infiltrating Lymphocytes (TILs)
Tumor CD73 Expression
CD133 Tumor
TIL Count
Programmed Cell Death-ligand 1
Online Access:https://doi.org/10.1038/s41598-018-33927-5

Internet

https://doi.org/10.1038/s41598-018-33927-5

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