Neurotrophin receptor p75 mediates amyloid β-induced tau pathology

Neurotrophin receptor p75 mediates amyloid β-induced tau pathology

Neurofibrillary tangles of hyperphosphorylated tau protein (p-tau) are a key pathological feature of Alzheimer's disease (AD). Tau phosphorylation is suggested to be secondary to amyloid-beta (Aβ) accumulation. However, the mechanism by which Aβ induces tau phosphorylation in neurons remains un...

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Bibliographic Details
Main Authors: Lin-Lin Shen, Wei-Wei Li, Ya-Li Xu, Shi-Hao Gao, Man-Yu Xu, Xian-Le Bu, Yu-Hui Liu, Jun Wang, Jie Zhu, Fan Zeng, Xiu-Qing Yao, Chang-Yue Gao, Zhi-Qiang Xu, Xin-Fu Zhou, Yan-Jiang Wang
Format: Article
Language:English
Published: Elsevier 2019-12-01
Series:Neurobiology of Disease
Subjects:
Amyloid-beta
p75NTR
Neurodegeneration
Tau phosphorylation
CDK5
GSK3β
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996119302359

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http://www.sciencedirect.com/science/article/pii/S0969996119302359

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