Signatures of HIV-1 subtype B and C Tat proteins and their effects in the neuropathogenesis of HIV-associated neurocognitive impairments

Signatures of HIV-1 subtype B and C Tat proteins and their effects in the neuropathogenesis of HIV-associated neurocognitive impairments

HIV-associated neurocognitive impairments (HANI) are a spectrum of neurological disorders due to the effects of HIV-1 on the central nervous system (CNS). The HIV-1 subtypes; HIV-1 subtype B (HIV-1B) and HIV-1 subtype C (HIV-1C) are responsible for the highest prevalence of HANI and HIV infections r...

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Bibliographic Details
Main Authors: Monray E. Williams, Simo S. Zulu, Dan J. Stein, John A. Joska, Petrus J.W. Naudé
Format: Article
Language:English
Published: Elsevier 2020-03-01
Series:Neurobiology of Disease
Subjects:
HIV Tat
Inflammation
Monocyte activation
BBB dysfunction
Tat polymorphisms
Neurovirulence and cognitive impairment
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996119303766

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http://www.sciencedirect.com/science/article/pii/S0969996119303766

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