Synthesis and Evaluation of Some 17-Acetamidoandrostane and N,N-Dimethyl-7-deoxycholic Amide Derivatives as Cytotoxic Agents: Structure/Activity Studies

Synthesis and Evaluation of Some 17-Acetamidoandrostane and N,N-Dimethyl-7-deoxycholic Amide Derivatives as Cytotoxic Agents: Structure/Activity Studies

Using pregnenolone and 7-deoxycholic acid as starting materials, some 17-acetamidoandrostane and N,N-dimethyl-7-deoxycholic amide derivatives were synthesized. The cytotoxicity of the synthesized compounds was tested in vitro against two tumor cell lines: SGC 7901 (human gastric carcinoma) and Bel 7...

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Bibliographic Details
Main Authors: Aimin Zhou, Chun Zeng, Huacan Song, Chunfang Gan, Linyi Jia, Jianguo Cui, Yanmin Huang
Format: Article
Language:English
Published: MDPI AG 2013-06-01
Series:Molecules
Subjects:
pregnenolone
17-acetamidoandrostane
N,N-dimethyl-7-deoxycholic amide
antiproliferative activity
Online Access:http://www.mdpi.com/1420-3049/18/7/7436

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http://www.mdpi.com/1420-3049/18/7/7436

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