Widespread brain parenchymal HMGB1 and NF-κB neuroinflammatory responses upon cortical spreading depolarization in familial hemiplegic migraine type 1 mice

Widespread brain parenchymal HMGB1 and NF-κB neuroinflammatory responses upon cortical spreading depolarization in familial hemiplegic migraine type 1 mice

Neuroinflammatory changes involving neuronal HMGB1 release and astrocytic NF-κB nuclear translocation occur following cortical spreading depolarization (CSD) in wildtype (WT) mice but it is unknown to what extent this occurs in the migraine brain. We therefore investigated in familial hemiplegic mig...

Full description

Bibliographic Details
Main Authors: Anisa Dehghani, Thas Phisonkunkasem, Sinem Yilmaz Ozcan, Turgay Dalkara, Arn M.J.M. van den Maagdenberg, Else A. Tolner, Hulya Karatas
Format: Article
Language:English
Published: Elsevier 2021-08-01
Series:Neurobiology of Disease
Subjects:
HMGB1
NF-κB
NMDA receptor
Excitability
Neuron
Astrocyte
Online Access:http://www.sciencedirect.com/science/article/pii/S096999612100173X

Internet

http://www.sciencedirect.com/science/article/pii/S096999612100173X

Similar Items