MiR-509-3 augments the synthetic lethality of PARPi by regulating HR repair in PDX model of HGSOC

MiR-509-3 augments the synthetic lethality of PARPi by regulating HR repair in PDX model of HGSOC

Abstract Background PARP inhibitors have been the most promising target drugs with widely proven benefits among ovarian cancer patients. Although platinum-response, HR-related genes, or HRD genomic scar detection are acceptably used in assessment of Olaparib response, there are still evident limitat...

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Bibliographic Details
Main Authors: Chenggong Sun, Wenyu Cao, Chunping Qiu, Chengcheng Li, Samina Dongol, Zhiwei Zhang, Ruifen Dong, Kun Song, Xingsheng Yang, Qing Zhang, Beihua Kong
Format: Article
Language:English
Published: BMC 2020-01-01
Series:Journal of Hematology & Oncology
Subjects:
miR-509-3
PARPi
Synthetic lethality
RAD51
PDX
Online Access:https://doi.org/10.1186/s13045-020-0844-0

Internet

https://doi.org/10.1186/s13045-020-0844-0

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