AML-Related NPM Mutations Drive p53 Delocalization into the Cytoplasm with Possible Impact on p53-Dependent Stress Response

AML-Related NPM Mutations Drive p53 Delocalization into the Cytoplasm with Possible Impact on p53-Dependent Stress Response

Nucleophosmin (NPM) interaction with tumor suppressor p53 is a part of a complex interaction network and considerably affects cellular stress response. The impact of <i>NPM1</i> mutations on its interaction with p53 has not been investigated yet, although consequences of NPMmut-induced p...

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Bibliographic Details
Main Authors: Aleš Holoubek, Dita Strachotová, Petra Otevřelová, Pavla Röselová, Petr Heřman, Barbora Brodská
Format: Article
Language:English
Published: MDPI AG 2021-06-01
Series:Cancers
Subjects:
p53
nucleophosmin
mutation
acute myeloid leukemia
FLIM-FRET
Selinexor
Online Access:https://www.mdpi.com/2072-6694/13/13/3266

Internet

https://www.mdpi.com/2072-6694/13/13/3266

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