N-chlorotaurine, a long-lived oxidant produced by human leukocytes, inactivates Shiga toxin of enterohemorrhagic Escherichia coli.

N-chlorotaurine, a long-lived oxidant produced by human leukocytes, inactivates Shiga toxin of enterohemorrhagic Escherichia coli.

N-chlorotaurine (NCT), the main representative of long-lived oxidants produced by granulocytes and monocytes, is known to exert broad-spectrum microbicidal activity. Here we show that NCT directly inactivates Shiga toxin 2 (Stx2), used as a model toxin secreted by enterohemorrhagic Escherichia coli...

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Bibliographic Details
Main Authors: Christian Eitzinger, Silvia Ehrlenbach, Herbert Lindner, Leopold Kremser, Waldemar Gottardi, Dmitri Debabov, Mark Anderson, Markus Nagl, Dorothea Orth
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3491008?pdf=render

Internet

http://europepmc.org/articles/PMC3491008?pdf=render

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