Inhibitory immune checkpoints PDCD-1 and LAG-3 hypermethylation may reduce the risk of colorectal cancer

Inhibitory immune checkpoints PDCD-1 and LAG-3 hypermethylation may reduce the risk of colorectal cancer

Abstract Background Changes in DNA methylation of immunosuppressive checkpoints may impact express and consequently affect antigen processing and presentation by tumor cells and facilitates evasion of immunosurveillance and lead to colorectal cancer (CRC). This study is to investigate the effect of...

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Bibliographic Details
Main Authors: Yuanyuan Zhang, Lei zhang, Hongru Sun, Ying Liu, Jing Xu, Hao Huang, Jinming Fu, Ding Zhang, Tian Tian, Yashuang Zhao, Guiyu Wang
Format: Article
Language:English
Published: BMC 2021-09-01
Series:Molecular Medicine
Subjects:
Colorectal cancer
Peripheral blood leukocyte
PDCD-1
LAG-3
DNA methylation
Online Access:https://doi.org/10.1186/s10020-021-00373-5

Internet

https://doi.org/10.1186/s10020-021-00373-5

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