The expression of Drosha, DGCR8, Dicer and Ago-2 genes are upregulated in human umbilical vein endothelial cells under hyperglycemic condition
Objectives. It has been shown that dysregulation of miRNAs expression contributes to the pathogenesis and progression of the diabetes and diabetes-related complications. Drosha, DGCR8, Dicer, and Ago-2 are involved in the miRNA maturation. The aim of the present study was to investigate the mRNA exp...
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2018-07-01
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| Series: | Endocrine Regulations |
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| Online Access: | https://doi.org/10.2478/enr-2018-0014 |
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doaj-60ce62fdee6a46b2a9f816e81e3a971a2021-09-05T21:00:49ZengSciendoEndocrine Regulations1336-03292018-07-0152312312710.2478/enr-2018-0014enr-2018-0014The expression of Drosha, DGCR8, Dicer and Ago-2 genes are upregulated in human umbilical vein endothelial cells under hyperglycemic conditionSoufi Farhad Ghadiri0Zonouzi Ali Akbar Poursadegh1Eftekhar Ebrahim2Kamali Kamila3Chegeni Sara Aghakhani4Zonouzi Ahmad Poursadegh5Molecular Medicine Research Center, Hormozgan Health institute, Hormozgan University of Medical Sciences, Bandar Abbas, IranDepartment of Genetics and Medical Biotechnology, Faculty of Medicine, Hormozgan University of Medical Sciences, Bandar Abbas, IranMolecular Medicine Research Center, Hormozgan Health institute, Hormozgan University of Medical Sciences, Bandar Abbas, IranLarestan University of Medical Sciences, Larestan, IranStudent Research Committee, Hormozgan University of Medical Sciences, Bandar Abbas, IranBiotechnology Research Center, Tabriz University of Medical Sciences, Tabriz, IranObjectives. It has been shown that dysregulation of miRNAs expression contributes to the pathogenesis and progression of the diabetes and diabetes-related complications. Drosha, DGCR8, Dicer, and Ago-2 are involved in the miRNA maturation. The aim of the present study was to investigate the mRNA expression levels of these genes in the human umbilical vein endothelial cells (HUVECs) under hyperglycemic condition.https://doi.org/10.2478/enr-2018-0014hyperglycemiadroshadgcr8dicerago-2human umbilical vein endothelial cells |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Soufi Farhad Ghadiri Zonouzi Ali Akbar Poursadegh Eftekhar Ebrahim Kamali Kamila Chegeni Sara Aghakhani Zonouzi Ahmad Poursadegh |
| spellingShingle |
Soufi Farhad Ghadiri Zonouzi Ali Akbar Poursadegh Eftekhar Ebrahim Kamali Kamila Chegeni Sara Aghakhani Zonouzi Ahmad Poursadegh The expression of Drosha, DGCR8, Dicer and Ago-2 genes are upregulated in human umbilical vein endothelial cells under hyperglycemic condition Endocrine Regulations hyperglycemia drosha dgcr8 dicer ago-2 human umbilical vein endothelial cells |
| author_facet |
Soufi Farhad Ghadiri Zonouzi Ali Akbar Poursadegh Eftekhar Ebrahim Kamali Kamila Chegeni Sara Aghakhani Zonouzi Ahmad Poursadegh |
| author_sort |
Soufi Farhad Ghadiri |
| title |
The expression of Drosha, DGCR8, Dicer and Ago-2 genes are upregulated in human umbilical vein endothelial cells under hyperglycemic condition |
| title_short |
The expression of Drosha, DGCR8, Dicer and Ago-2 genes are upregulated in human umbilical vein endothelial cells under hyperglycemic condition |
| title_full |
The expression of Drosha, DGCR8, Dicer and Ago-2 genes are upregulated in human umbilical vein endothelial cells under hyperglycemic condition |
| title_fullStr |
The expression of Drosha, DGCR8, Dicer and Ago-2 genes are upregulated in human umbilical vein endothelial cells under hyperglycemic condition |
| title_full_unstemmed |
The expression of Drosha, DGCR8, Dicer and Ago-2 genes are upregulated in human umbilical vein endothelial cells under hyperglycemic condition |
| title_sort |
expression of drosha, dgcr8, dicer and ago-2 genes are upregulated in human umbilical vein endothelial cells under hyperglycemic condition |
| publisher |
Sciendo |
| series |
Endocrine Regulations |
| issn |
1336-0329 |
| publishDate |
2018-07-01 |
| description |
Objectives. It has been shown that dysregulation of miRNAs expression contributes to the pathogenesis and progression of the diabetes and diabetes-related complications. Drosha, DGCR8, Dicer, and Ago-2 are involved in the miRNA maturation. The aim of the present study was to investigate the mRNA expression levels of these genes in the human umbilical vein endothelial cells (HUVECs) under hyperglycemic condition. |
| topic |
hyperglycemia drosha dgcr8 dicer ago-2 human umbilical vein endothelial cells |
| url |
https://doi.org/10.2478/enr-2018-0014 |
| work_keys_str_mv |
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1717782154912464896 |