Selective carboxylation of reactive benzylic C–H bonds by a hypervalent iodine(III)/inorganic bromide oxidation system

Selective carboxylation of reactive benzylic C–H bonds by a hypervalent iodine(III)/inorganic bromide oxidation system

An oxidation system comprising phenyliodine(III) diacetate (PIDA) and iodosobenzene with inorganic bromide, i.e., sodium bromide, in an organic solvent led to the direct introduction of carboxylic acids into benzylic C–H bonds under mild conditions. The unique radical species, generated by the homol...

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Bibliographic Details
Main Authors: Toshifumi Dohi, Shohei Ueda, Kosuke Iwasaki, Yusuke Tsunoda, Koji Morimoto, Yasuyuki Kita
Format: Article
Language:English
Published: Beilstein-Institut 2018-05-01
Series:Beilstein Journal of Organic Chemistry
Subjects:
carboxylic acids
C–H activation
iodine
oxygenation
radicals
Online Access:https://doi.org/10.3762/bjoc.14.94

Internet

https://doi.org/10.3762/bjoc.14.94

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