A-kinase anchoring protein BIG3 coordinates oestrogen signalling in breast cancer cells
BIG3 is highly expressed in breast cancers and its interaction with PHB2 results in constitutive activation of E2/ERa signalling. Here the authors unveil the mechanistic details of this regulation showing that BIG3 binds PKA and regulates PP1Ca activity in an oestrogen-dependent manner.
Bibliographic Details
Main Authors: |
Tetsuro Yoshimaru,
Masaya Ono,
Yoshimi Bando,
Yi-An Chen,
Kenji Mizuguchi,
Hiroshi Shima,
Masato Komatsu,
Issei Imoto,
Keisuke Izumi,
Junko Honda,
Yasuo Miyoshi,
Mitsunori Sasa,
Toyomasa Katagiri |
Format: | Article
|
Language: | English |
Published: |
Nature Publishing Group
2017-05-01
|
Series: | Nature Communications
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Online Access: | https://doi.org/10.1038/ncomms15427
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