A-kinase anchoring protein BIG3 coordinates oestrogen signalling in breast cancer cells

BIG3 is highly expressed in breast cancers and its interaction with PHB2 results in constitutive activation of E2/ERa signalling. Here the authors unveil the mechanistic details of this regulation showing that BIG3 binds PKA and regulates PP1Ca activity in an oestrogen-dependent manner.

Bibliographic Details
Main Authors:	Tetsuro Yoshimaru, Masaya Ono, Yoshimi Bando, Yi-An Chen, Kenji Mizuguchi, Hiroshi Shima, Masato Komatsu, Issei Imoto, Keisuke Izumi, Junko Honda, Yasuo Miyoshi, Mitsunori Sasa, Toyomasa Katagiri
Format:	Article
Language:	English
Published:	Nature Publishing Group 2017-05-01
Series:	Nature Communications
Online Access:	https://doi.org/10.1038/ncomms15427

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spelling	doaj-60d347e4facc4c32a918af21f2d88d682021-05-11T07:11:17ZengNature Publishing GroupNature Communications2041-17232017-05-018111210.1038/ncomms15427A-kinase anchoring protein BIG3 coordinates oestrogen signalling in breast cancer cellsTetsuro Yoshimaru0Masaya Ono1Yoshimi Bando2Yi-An Chen3Kenji Mizuguchi4Hiroshi Shima5Masato Komatsu6Issei Imoto7Keisuke Izumi8Junko Honda9Yasuo Miyoshi10Mitsunori Sasa11Toyomasa Katagiri12Division of Genome Medicine, Institute for Genome Research, Tokushima UniversityDivision of Chemotherapy and Clinical Research, National Cancer Center Research InstituteDivision of Pathology, Tokushima University HospitalNational Institutes of Biomedical Innovation, Health and NutritionNational Institutes of Biomedical Innovation, Health and NutritionDivision of Cancer Chemotherapy, Miyagi Cancer Center Research InstituteDivision of Genome Medicine, Institute for Genome Research, Tokushima UniversityDepartment of Human Genetics, Institute of Biomedical Sciences, Tokushima University Graduate SchoolDepartment of Molecular and Environmental Pathology, Graduate School of Medicine, Tokushima University Graduate SchoolDepartment of Surgery, National Hospital Organization Higashitokushima Medical CenterDepartment of Surgery, Division of Breast and Endocrine Surgery, Hyogo College of MedicineDepartment of Surgery, Tokushima Breast Care ClinicDivision of Genome Medicine, Institute for Genome Research, Tokushima UniversityBIG3 is highly expressed in breast cancers and its interaction with PHB2 results in constitutive activation of E2/ERa signalling. Here the authors unveil the mechanistic details of this regulation showing that BIG3 binds PKA and regulates PP1Ca activity in an oestrogen-dependent manner.https://doi.org/10.1038/ncomms15427
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Tetsuro Yoshimaru Masaya Ono Yoshimi Bando Yi-An Chen Kenji Mizuguchi Hiroshi Shima Masato Komatsu Issei Imoto Keisuke Izumi Junko Honda Yasuo Miyoshi Mitsunori Sasa Toyomasa Katagiri
spellingShingle	Tetsuro Yoshimaru Masaya Ono Yoshimi Bando Yi-An Chen Kenji Mizuguchi Hiroshi Shima Masato Komatsu Issei Imoto Keisuke Izumi Junko Honda Yasuo Miyoshi Mitsunori Sasa Toyomasa Katagiri A-kinase anchoring protein BIG3 coordinates oestrogen signalling in breast cancer cells Nature Communications
author_facet	Tetsuro Yoshimaru Masaya Ono Yoshimi Bando Yi-An Chen Kenji Mizuguchi Hiroshi Shima Masato Komatsu Issei Imoto Keisuke Izumi Junko Honda Yasuo Miyoshi Mitsunori Sasa Toyomasa Katagiri
author_sort	Tetsuro Yoshimaru
title	A-kinase anchoring protein BIG3 coordinates oestrogen signalling in breast cancer cells
title_short	A-kinase anchoring protein BIG3 coordinates oestrogen signalling in breast cancer cells
title_full	A-kinase anchoring protein BIG3 coordinates oestrogen signalling in breast cancer cells
title_fullStr	A-kinase anchoring protein BIG3 coordinates oestrogen signalling in breast cancer cells
title_full_unstemmed	A-kinase anchoring protein BIG3 coordinates oestrogen signalling in breast cancer cells
title_sort	a-kinase anchoring protein big3 coordinates oestrogen signalling in breast cancer cells
publisher	Nature Publishing Group
series	Nature Communications
issn	2041-1723
publishDate	2017-05-01
description	BIG3 is highly expressed in breast cancers and its interaction with PHB2 results in constitutive activation of E2/ERa signalling. Here the authors unveil the mechanistic details of this regulation showing that BIG3 binds PKA and regulates PP1Ca activity in an oestrogen-dependent manner.
url	https://doi.org/10.1038/ncomms15427
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A-kinase anchoring protein BIG3 coordinates oestrogen signalling in breast cancer cells

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