Role of electrical activity in horizontal axon growth in the developing cortex: a time-lapse study using optogenetic stimulation.

During development, layer 2/3 neurons in the neocortex extend their axons horizontally, within the same layers, and stop growing at appropriate locations to form branches and synaptic connections. Firing and synaptic activity are thought to be involved in this process, but how neuronal activity regu...

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Bibliographic Details
Main Authors: Olga Malyshevskaya, Yoshihiro Shiraishi, Fumitaka Kimura, Nobuhiko Yamamoto
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3871609?pdf=render