MicroRNA-499 serves as a sensitizer for lung cancer cells to radiotherapy by inhibition of CK2α-mediated phosphorylation of p65

MicroRNA-499 serves as a sensitizer for lung cancer cells to radiotherapy by inhibition of CK2α-mediated phosphorylation of p65

The present study aimed to define the tumor-suppressive role of microRNA-499 (miR-499) in lung cancer cells and its underlying mechanism. First, qRT-PCR analysis revealed poor expression of miR-499 in clinical samples and cell lines of lung cancer. Next, we performed loss- and gain-of-function exper...

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Bibliographic Details
Main Authors: Yu-Shui Ma, Bo-Wen Shi, Hai-Min Lu, Peng-Fei Xie, Rui Xin, Zhi-Jun Wu, Yi Shi, Yu-Zhen Yin, Li-Kun Hou, Cheng-You Jia, Wei Wu, Zhong-Wei Lv, Fei Yu, Gao-Ren Wang, Ji-Bin Liu, Geng-Xi Jiang, Da Fu
Format: Article
Language:English
Published: Elsevier 2021-06-01
Series:Molecular Therapy: Oncolytics
Subjects:
microRNA-499
casein kinase 2 alpha
lung cancer
radiotherapy sensitivity
p65 phosphorylation
Online Access:http://www.sciencedirect.com/science/article/pii/S2372770521000504

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http://www.sciencedirect.com/science/article/pii/S2372770521000504

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