Prioritizing transcriptional factors in gene regulatory networks with PageRank

Prioritizing transcriptional factors in gene regulatory networks with PageRank

Summary: Biological states are controlled by orchestrated transcriptional factors (TFs) within gene regulatory networks. Here we show TFs responsible for the dynamic changes of biological states can be prioritized with temporal PageRank. We further show such TF prioritization can be extended by inte...

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Bibliographic Details
Main Authors: Hongxu Ding, Ying Yang, Yuanqing Xue, Lucas Seninge, Henry Gong, Rojin Safavi, Andrea Califano, Joshua M. Stuart
Format: Article
Language:English
Published: Elsevier 2021-01-01
Series:iScience
Subjects:
Gene Network
Molecular Biology
Omics
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004220312141

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http://www.sciencedirect.com/science/article/pii/S2589004220312141

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