C. elegans BLOC-1 functions in trafficking to lysosome-related gut granules.

C. elegans BLOC-1 functions in trafficking to lysosome-related gut granules.

The human disease Hermansky-Pudlak syndrome results from defective biogenesis of lysosome-related organelles (LROs) and can be caused by mutations in subunits of the BLOC-1 complex. Here we show that C. elegans glo-2 and snpn-1, despite relatively low levels of amino acid identity, encode Pallidin a...

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Bibliographic Details
Main Authors: Greg J Hermann, Emily Scavarda, Allison M Weis, Daniel S Saxton, Laura L Thomas, Rebecca Salesky, Hannah Somhegyi, Thomas P Curtin, Alec Barrett, Olivia K Foster, Annalise Vine, Katherine Erlich, Elizabeth Kwan, Beverley M Rabbitts, Kaila Warren
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3419718?pdf=render

Internet

http://europepmc.org/articles/PMC3419718?pdf=render

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