The Xanthine Oxidase Inhibitor Febuxostat Suppresses the Progression of IgA Nephropathy, Possibly via Its Anti-Inflammatory and Anti-Fibrotic Effects in the gddY Mouse Model

The Xanthine Oxidase Inhibitor Febuxostat Suppresses the Progression of IgA Nephropathy, Possibly via Its Anti-Inflammatory and Anti-Fibrotic Effects in the gddY Mouse Model

Recent clinical studies have demonstrated the protective effect of xanthine oxidase (XO) inhibitors against chronic kidney diseases, although the underlying molecular mechanisms remain unclear. However, to date, neither clinical nor basic research has been carried out to elucidate the efficacy of XO...

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Bibliographic Details
Main Authors: Masa-Ki Inoue, Takeshi Yamamotoya, Yusuke Nakatsu, Koji Ueda, Yuki Inoue, Yasuka Matsunaga, Hideyuki Sakoda, Midori Fujishiro, Hiraku Ono, Kenichi Morii, Kensuke Sasaki, Takao Masaki, Yusuke Suzuki, Tomoichiro Asano, Akifumi Kushiyama
Format: Article
Language:English
Published: MDPI AG 2018-12-01
Series:International Journal of Molecular Sciences
Subjects:
IgA nephropathy
xanthine oxidase inhibitor
Febuxostat
Inflammation
Fibrosis
Online Access:https://www.mdpi.com/1422-0067/19/12/3967

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https://www.mdpi.com/1422-0067/19/12/3967

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