Pharmacophore Models and Pharmacophore-Based Virtual Screening: Concepts and Applications Exemplified on Hydroxysteroid Dehydrogenases

Pharmacophore Models and Pharmacophore-Based Virtual Screening: Concepts and Applications Exemplified on Hydroxysteroid Dehydrogenases

Computational methods are well-established tools in the drug discovery process and can be employed for a variety of tasks. Common applications include lead identification and scaffold hopping, as well as lead optimization by structure-activity relationship analysis and selectivity profiling. In addi...

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Bibliographic Details
Main Authors: Teresa Kaserer, Katharina R. Beck, Muhammad Akram, Alex Odermatt, Daniela Schuster
Format: Article
Language:English
Published: MDPI AG 2015-12-01
Series:Molecules
Subjects:
pharmacophore
virtual screening
ligand protein interactions
hydroxysteroid dehydrogenase
oxidoreductase
Online Access:http://www.mdpi.com/1420-3049/20/12/19880

Internet

http://www.mdpi.com/1420-3049/20/12/19880

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