Artifactual hyperpolarization during extracellular electrical stimulation: Proposed mechanism of high-rate neuromodulation disproved

Background: Kilohertz-frequency electric field stimulation (kEFS) applied to the spinal cord can reduce chronic pain without causing the buzzing sensation (paresthesia) associated with activation of dorsal column fibers. This suggests that high-rate spinal cord stimulation (SCS) has a mode of action...

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Bibliographic Details
Main Authors: L. Stephen Lesperance, Milad Lankarany, Tianhe C. Zhang, Rosana Esteller, Stéphanie Ratté, Steven A. Prescott
Format: Article
Language:English
Published: Elsevier 2018-05-01
Series:Brain Stimulation
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S1935861X17310203