Human Cyclophilin B forms part of a multi-protein complex during erythrocyte invasion by Plasmodium falciparum

Human Cyclophilin B forms part of a multi-protein complex during erythrocyte invasion by Plasmodium falciparum

Invasion of red blood cells by Plasmodium falciparum is a complex process and relies on several receptor-ligand interactions. Here, the authors show that human cyclophilin B binds Plasmodium surface protein PfRhopH3 and that interruption of this interaction reduces invasion by 80%.

Bibliographic Details
Main Authors: Prem Prakash, Mohammad Zeeshan, Ekta Saini, Azhar Muneer, Sachin Khurana, Bishwanath Kumar Chourasia, Arunaditya Deshmukh, Inderjeet Kaur, Surabhi Dabral, Niharika Singh, Zille Anam, Ayushi Chaurasiya, Shikha Kaushik, Pradeep Dahiya, Md. Kalamuddin, Jitendra Kumar Thakur, Asif Mohmmed, Anand Ranganathan, Pawan Malhotra
Format: Article
Language:English
Published: Nature Publishing Group 2017-11-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-017-01638-6

Internet

https://doi.org/10.1038/s41467-017-01638-6

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