Inhibitory role of Notch1 in calcific aortic valve disease.
Aortic valve calcification is the most common form of valvular heart disease, but the mechanisms of calcific aortic valve disease (CAVD) are unknown. NOTCH1 mutations are associated with aortic valve malformations and adult-onset calcification in families with inherited disease. The Notch signaling...
Main Authors: | Asha Acharya, Chetan P Hans, Sara N Koenig, Haley A Nichols, Cristi L Galindo, Harold R Garner, Walter H Merrill, Robert B Hinton, Vidu Garg |
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Format: | Article |
Language: | English |
Published: |
Public Library of Science (PLoS)
2011-01-01
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Series: | PLoS ONE |
Online Access: | http://europepmc.org/articles/PMC3218038?pdf=render |
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