Adenovirus VA RNAI Blocks ASC Oligomerization and Inhibits NLRP3 Inflammasome Activation

Adenovirus VA RNAI Blocks ASC Oligomerization and Inhibits NLRP3 Inflammasome Activation

Virus infected immune cells can rapidly respond to the invader by activating the inflammasome and as a consequence release proinflammatory cytokines and eventually die by pyroptosis. In human adenovirus-5 (Ad5) infected THP-1 cells, inhibition of NLRP3 inflammasome activation was demonstrated by a d...

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Bibliographic Details
Main Authors: Mahmoud Darweesh, Wael Kamel, Mikhail A. Gavrilin, Göran Akusjärvi, Catharina Svensson
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-11-01
Series:Frontiers in Immunology
Subjects:
adenovirus
inflammasome
VA RNAI
PKR
proinflammatory cytokines
NLRP3
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2019.02791/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2019.02791/full

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