Sortilin Fragments Deposit at Senile Plaques in Human Cerebrum

Sortilin Fragments Deposit at Senile Plaques in Human Cerebrum

Genetic variations in the vacuolar protein sorting 10 protein (Vps10p) family have been linked to Alzheimer’s disease (AD). Here we demonstrate deposition of fragments from the Vps10p member sortilin at senile plaques (SPs) in aged and AD human cerebrum. Sortilin changes were characterized in postmo...

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Bibliographic Details
Main Authors: Xia Hu, Zhao-Lan Hu, Zheng Li, Chun-Sheng Ruan, Wen-Ying Qiu, Aihua Pan, Chang-Qi Li, Yan Cai, Lu Shen, Yaping Chu, Bei-Sha Tang, Huaibin Cai, Xin-Fu Zhou, Chao Ma, Xiao-Xin Yan
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-06-01
Series:Frontiers in Neuroanatomy
Subjects:
Alzheimer’s disease
amyloid deposition
neuritic plaques
synaptic pathology
Vps10p family proteins
Online Access:http://journal.frontiersin.org/article/10.3389/fnana.2017.00045/full

Internet

http://journal.frontiersin.org/article/10.3389/fnana.2017.00045/full

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