Sirt1 coordinates with ERα to regulate autophagy and adiposity

Abstract Sex difference in adiposity has long been recognized but the mechanism remains incompletely understood. Previous studies suggested that adiposity was regulated by autophagy in response to energy status change. Here, we show that the energy sensor Sirt1 mediates sex difference in adiposity b...

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Bibliographic Details
Main Authors: Zhipeng Tao, Limin Shi, Jane Parke, Louise Zheng, Wei Gu, X. Charlie Dong, Dongmin Liu, Zongwei Wang, Aria F. Olumi, Zhiyong Cheng
Format: Article
Language:English
Published: Nature Publishing Group 2021-03-01
Series:Cell Death Discovery
Online Access:https://doi.org/10.1038/s41420-021-00438-8