Synthesis of the reported structure of piperazirum using a nitro-Mannich reaction as the key stereochemical determining step

Piperazirum, isolated from Arum palaestinum Boiss, was originally assigned as r-3,c-5-diisobutyl-c-6-isopropylpiperazin-2-one. The reported structure was synthesised diastereoselectively using a key nitro-Mannich reaction to set up the C5/C6 relative stereochemistry. The structure was unambiguously...

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Bibliographic Details
Main Authors: James C. Anderson, Andreas S. Kalogirou, Michael J. Porter, Graham J. Tizzard
Format: Article
Language:English
Published: Beilstein-Institut 2013-08-01
Series:Beilstein Journal of Organic Chemistry
Subjects:
Online Access:https://doi.org/10.3762/bjoc.9.200