CDKN1C (p57) is a direct target of EZH2 and suppressed by multiple epigenetic mechanisms in breast cancer cells.

CDKN1C (p57) is a direct target of EZH2 and suppressed by multiple epigenetic mechanisms in breast cancer cells.

CDKN1C (encoding tumor suppressor p57(KIP2)) is a cyclin-dependent kinase (CDK) inhibitor whose family members are often transcriptionally downregulated in human cancer via promoter DNA methylation. In this study, we show that CDKN1C is repressed in breast cancer cells mainly through histone modific...

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Bibliographic Details
Main Authors: Xiaojing Yang, R K Murthy Karuturi, Feng Sun, Meiyee Aau, Kun Yu, Rongguang Shao, Lance D Miller, Patrick Boon Ooi Tan, Qiang Yu
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2009-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC2659786?pdf=render

Internet

http://europepmc.org/articles/PMC2659786?pdf=render

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