Alterations in mitochondrial and endoplasmic reticulum signaling by p53 mutants

Alterations in mitochondrial and endoplasmic reticulum signaling by p53 mutants

The p53 protein is probably the most important tumor suppressor, acting as a nuclear transcription factor primarily through the modulation of cell death. However, currently, it is well accepted that p53 can also exert important transcription-independent pro-cell death actions. Indeed, cytosolic loca...

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Bibliographic Details
Main Authors: Carlotta eGiorgi, Massimo eBonora, Sonia eMissiroli, Claudia eMorganti, Giampaolo eMorciano, Mariusz R. Wieckowski, Paolo ePinton
Format: Article
Language:English
Published: Frontiers Media S.A. 2016-02-01
Series:Frontiers in Oncology
Subjects:
Apoptosis
Calcium
Cell Death
Endoplasmic Reticulum
Mitochondria
Online Access:http://journal.frontiersin.org/Journal/10.3389/fonc.2016.00042/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fonc.2016.00042/full

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