Chemical, Physical and Biological Triggers of Evolutionary Conserved Bcl-xL-mediated Apoptosis

Chemical, Physical and Biological Triggers of Evolutionary Conserved Bcl-xL-mediated Apoptosis

Background: The evidence that pan-Bcl-2 or Bcl-xL-specific inhibitors prematurely kill virus-infected or RNA/DNA-transfected cells provides rationale for investigating these apoptotic inducers further. We hypothesized that not only invasive RNA or DNA (biological factors) but also DNA/RNA-damaging c...

Full description

Bibliographic Details
Main Authors: Aleksandr Ianevski, Evgeny Kulesskiy, Klara Krpina, Guofeng Lou, Yahyah Aman, Andrii Bugai, Koit Aasumets, Yevhen Akimov, Daria Bulanova, Kiira Gildemann, Albert F. Arutyunyan, Olga Yu. Susova, Alexei L. Zhuze, Ping Ji, Wei Wang, Toril Holien, Marit Bugge, Eva Zusinaite, Valentyn Oksenych, Hilde Lysvand, Joachim M. Gerhold, Magnar Bjørås, Pål Johansen, Anders Waage, Caroline A. Heckman, Evandro F. Fang, Denis E. Kainov
Format: Article
Language:English
Published: MDPI AG 2020-06-01
Series:Cancers
Subjects:
apoptosis
Bcl-xL
oncolytics
navitoclax
Online Access:https://www.mdpi.com/2072-6694/12/6/1694

Internet

https://www.mdpi.com/2072-6694/12/6/1694

Similar Items