Loss of RET Promotes Mesenchymal Identity in Neuroblastoma Cells

Loss of RET Promotes Mesenchymal Identity in Neuroblastoma Cells

Aberrant activation of anaplastic lymphoma kinase (ALK) drives neuroblastoma (NB). Previous work identified the RET receptor tyrosine kinase (RTK) as a downstream target of ALK activity in NB models. We show here that ALK activation in response to ALKAL2 ligand results in the rapid phosphorylation o...

Full description

Bibliographic Details
Main Authors: Joachim T. Siaw, Jonatan L. Gabre, Ezgi Uçkun, Marc Vigny, Wancun Zhang, Jimmy Van den Eynden, Bengt Hallberg, Ruth H. Palmer, Jikui Guan
Format: Article
Language:English
Published: MDPI AG 2021-04-01
Series:Cancers
Subjects:
ALK
ALKAL2
EMT
neural differentiation
adrenergic
retinoic acid
Online Access:https://www.mdpi.com/2072-6694/13/8/1909

Internet

https://www.mdpi.com/2072-6694/13/8/1909

Similar Items