Mevalonate Pathway Regulates Cell Size Homeostasis and Proteostasis through Autophagy

Balance between cell growth and proliferation determines cell size homeostasis, but little is known about how metabolic pathways are involved in the maintenance of this balance. Here, we perform a screen with a library of clinically used drug molecules for their effects on cell size. We find that st...

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Bibliographic Details
Main Authors: Teemu P. Miettinen, Mikael Björklund
Format: Article
Language:English
Published: Elsevier 2015-12-01
Series:Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124715013601