Genetic variation in OAS1 is a risk factor for initial infection with West Nile virus in man.

Genetic variation in OAS1 is a risk factor for initial infection with West Nile virus in man.

West Nile virus (WNV) is a re-emerging pathogen that can cause fatal encephalitis. In mice, susceptibility to WNV has been reported to result from a single point mutation in oas1b, which encodes 2'-5' oligoadenylate synthetase 1b, a member of the type I interferon-regulated OAS gene family...

Full description

Bibliographic Details
Main Authors: Jean K Lim, Andrea Lisco, David H McDermott, Linda Huynh, Jerrold M Ward, Bernard Johnson, Hope Johnson, John Pape, Gregory A Foster, David Krysztof, Dean Follmann, Susan L Stramer, Leonid B Margolis, Philip M Murphy
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2009-02-01
Series:PLoS Pathogens
Online Access:http://europepmc.org/articles/PMC2642680?pdf=render

Internet

http://europepmc.org/articles/PMC2642680?pdf=render

Similar Items