Nonspecific Expression in Limited Excitatory Cell Populations in Interneuron-Targeting Cre-driver Lines Can Have Large Functional Effects

Nonspecific Expression in Limited Excitatory Cell Populations in Interneuron-Targeting Cre-driver Lines Can Have Large Functional Effects

Transgenic Cre-recombinase expressing mouse lines are widely used to express fluorescent proteins and opto-/chemogenetic actuators, making them a cornerstone of modern neuroscience. The investigation of interneurons in particular has benefitted from the ability to genetically target specific cell ty...

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Bibliographic Details
Main Authors: Daniel Müller-Komorowska, Thoralf Opitz, Shehabeldin Elzoheiry, Michaela Schweizer, Eleonora Ambrad Giovannetti, Heinz Beck
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-04-01
Series:Frontiers in Neural Circuits
Subjects:
Cre mouse line
cell-type specificity
optogenetics
interneuron
somatostatin
hippocampus
Online Access:https://www.frontiersin.org/article/10.3389/fncir.2020.00016/full

Internet

https://www.frontiersin.org/article/10.3389/fncir.2020.00016/full

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