Sam68/KHDRBS1 is critical for colon tumorigenesis by regulating genotoxic stress-induced NF-κB activation

Sam68/KHDRBS1 is critical for colon tumorigenesis by regulating genotoxic stress-induced NF-κB activation

Nuclear factor kappa B (NF-κB)-mediated transcription is an important mediator for cellular responses to DNA damage. Genotoxic agents trigger a 'nuclear-to-cytoplasmic' NF-κB activation signaling pathway; however, the early nuclear signaling cascade linking DNA damage and NF-κB activation...

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Bibliographic Details
Main Authors: Kai Fu, Xin Sun, Eric M Wier, Andrea Hodgson, Yue Liu, Cynthia L Sears, Fengyi Wan
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2016-07-01
Series:eLife
Subjects:
NF-kB
colon cancer
signal transduction
DNA damage responses
Sam68
KHDRBS1
Online Access:https://elifesciences.org/articles/15018

Internet

https://elifesciences.org/articles/15018

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