M1 Macrophages Promote TRAIL Expression in Adipose Tissue-Derived Stem Cells, Which Suppresses Colitis-Associated Colon Cancer by Increasing Apoptosis of CD133<sup>+</sup> Cancer Stem Cells and Decreasing M2 Macrophage Population

M1 Macrophages Promote TRAIL Expression in Adipose Tissue-Derived Stem Cells, Which Suppresses Colitis-Associated Colon Cancer by Increasing Apoptosis of CD133<sup>+</sup> Cancer Stem Cells and Decreasing M2 Macrophage Population

We have previously reported that adipose tissue-derived stem cells (ASCs) cultured at high cell density can induce cancer cell death through the expression of type I interferons and tumor necrosis factor (TNF)-related apoptosis-inducing ligands (TRAIL). Here, we investigated whether TRAIL-expressing...

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Bibliographic Details
Main Authors: Young Woo Eom, Rokeya Akter, Wanlu Li, Suji Lee, Soonjae Hwang, Jiye Kim, Mee-Yon Cho
Format: Article
Language:English
Published: MDPI AG 2020-05-01
Series:International Journal of Molecular Sciences
Subjects:
colitis-associated cancer
mesenchymal stem cells
CD133<sup>+</sup> cancer stem cells
tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)
apoptosis
Online Access:https://www.mdpi.com/1422-0067/21/11/3887

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https://www.mdpi.com/1422-0067/21/11/3887

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