A small-molecule pan-class I glucose transporter inhibitor reduces cancer cell proliferation in vitro and tumor growth in vivo by targeting glucose-based metabolism

A small-molecule pan-class I glucose transporter inhibitor reduces cancer cell proliferation in vitro and tumor growth in vivo by targeting glucose-based metabolism

Abstract Background Cancer cells drastically increase the uptake of glucose and glucose metabolism by overexpressing class I glucose transporters (GLUT1-4) to meet their energy and biomass synthesis needs and are very sensitive and vulnerable to glucose deprivation. Although targeting glucose uptake...

Full description

Bibliographic Details
Main Authors: Pratik Shriwas, Dennis Roberts, Yunsheng Li, Liyi Wang, Yanrong Qian, Stephen Bergmeier, Jennifer Hines, Subhodip Adhicary, Corinne Nielsen, Xiaozhuo Chen
Format: Article
Language:English
Published: BMC 2021-03-01
Series:Cancer & Metabolism
Subjects:
The Warburg effect
Glycolysis
TCA cycle
Metabolomics
Anticancer therapeutics
docking
Online Access:https://doi.org/10.1186/s40170-021-00248-7

Internet

https://doi.org/10.1186/s40170-021-00248-7

Similar Items