A non-canonical pathway regulates ER stress signaling and blocks ER stress-induced apoptosis and heart failure

A non-canonical pathway regulates ER stress signaling and blocks ER stress-induced apoptosis and heart failure

Endoplasmic reticulum (ER) stress promotes cardiac dysfunction. Here the authors uncover a pathway whereby AGGF1 blocks ER stress by inhibiting ERK1/2 activation and the transcriptional repressor ZEB1, leading to induction of miR-183-5p and down-regulation of CHOP, and show that AGGF1 can effectivel...

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Bibliographic Details
Main Authors: Yufeng Yao, Qiulun Lu, Zhenkun Hu, Yubin Yu, Qiuyun Chen, Qing K. Wang
Format: Article
Language:English
Published: Nature Publishing Group 2017-07-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-017-00171-w

Internet

https://doi.org/10.1038/s41467-017-00171-w

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