A sensitive and specific ELISA detects methionine sulfoxide-containing apolipoprotein A-I in HDL*

A sensitive and specific ELISA detects methionine sulfoxide-containing apolipoprotein A-I in HDL*

Oxidized HDL has been proposed to play a key role in atherogenesis. A wide range of reactive intermediates oxidizes methionine residues to methionine sulfoxide (MetO) in apolipoprotein A-I (apoA-I), the major HDL protein. These reactive species include those produced by myeloperoxidase, an enzyme im...

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Bibliographic Details
Main Authors: Xiao Suo Wang, Baohai Shao, Michael N. Oda, Jay W. Heinecke, Stephen Mahler, Roland Stocker
Format: Article
Language:English
Published: Elsevier 2009-03-01
Series:Journal of Lipid Research
Subjects:
protein oxidation
lipid hydroperoxides
dysfunctional HDL
myeloperoxidase
oxidative stress
reactive nitrogen species
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520309019

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http://www.sciencedirect.com/science/article/pii/S0022227520309019

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