Potent sialic acid inhibitors that target influenza A virus hemagglutinin

Abstract Eradicating influenza A virus (IAV) is difficult, due to its genetic drift and reassortment ability. As the infectious cycle is initiated by the influenza glycoprotein, hemagglutinin (HA), which mediates the binding of virions to terminal sialic acids moieties, HA is a tempting target of an...

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Bibliographic Details
Main Authors: Yu-Jen Chang, Cheng-Yun Yeh, Ju-Chien Cheng, Yu-Qi Huang, Kai-Cheng Hsu, Yu-Feng Lin, Chih-Hao Lu
Format: Article
Language:English
Published: Nature Publishing Group 2021-04-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-021-87845-0