Novel Inhibitors of Nicotinamide-<i>N</i>-Methyltransferase for the Treatment of Metabolic Disorders

Novel Inhibitors of Nicotinamide-<i>N</i>-Methyltransferase for the Treatment of Metabolic Disorders

Nicotinamide-<i>N</i>-methyltransferase (NNMT) is a cytosolic enzyme catalyzing the transfer of a methyl group from <i>S</i>-adenosyl-methionine (SAM) to nicotinamide (Nam). It is expressed in many tissues including the liver, adipose tissue, and skeletal muscle. Its expressi...

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Bibliographic Details
Main Authors: Aimo Kannt, Sridharan Rajagopal, Mahanandeesha S. Hallur, Indu Swamy, Rajendra Kristam, Saravanakumar Dhakshinamoorthy, Joerg Czech, Gernot Zech, Herman Schreuder, Sven Ruf
Format: Article
Language:English
Published: MDPI AG 2021-02-01
Series:Molecules
Subjects:
nicotinamide-<i>N</i>-methyltransferase
small molecule inhibitor
nicotinamide
metabolic disease
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Online Access:https://www.mdpi.com/1420-3049/26/4/991

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https://www.mdpi.com/1420-3049/26/4/991

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